Dissecting signaling through activation of specific Src-effector complexes in vivo

We describe an approach to selectively activate a kinase in a specific protein complex or at a specific subcellular location within living cells, and within minutes. This reveals the effects of specific kinase pathways without time for genetic compensation. The new technique, dubbed RapRTAP (rapamyc...

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Bibliografiske detaljer
Main Authors: Karginov, A.V., Tsygankov, D., Berginski, M., Chu, P.-H., Trudeau, E.D., Yi, J.J., Gomez, S., Elston, T.C., Hahn, K.M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064790/
https://ncbi.nlm.nih.gov/pubmed/24609359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1477
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