Negative selection of semimature CD4(+)8(-)HSA(+) thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling

T cell receptor/CD3 ligation induces apoptosis in semimature CD4(+)8(-)HSA(+) thymocytes, and this helps establish immunological tolerance and constitutes one of the safeguards against autoimmune disease. We analyzed several knockout and transgenic mouse lines and found that T cell receptor/CD3-liga...

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Bibliographic Details
Main Authors: Villunger, Andreas, Marsden, Vanessa S., Zhan, Yifan, Erlacher, Miriam, Lew, Andrew M., Bouillet, Philippe, Berzins, Stuart, Godfrey, Dale I., Heath, William R., Strasser, Andreas
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC406464/
https://ncbi.nlm.nih.gov/pubmed/15118096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0305757101
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