Testing protein-folding simulations by experiment: B domain of protein A
We have assessed the published predictions of the pathway of folding of the B domain of protein A, the pathway most studied by computer simulation. We analyzed the transition state for folding of the three-helix bundle protein, by using experimental Φ values on some 70 suitable mutants. Surprisingly...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC406447/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15069202/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401396101 |
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