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Testing protein-folding simulations by experiment: B domain of protein A
We have assessed the published predictions of the pathway of folding of the B domain of protein A, the pathway most studied by computer simulation. We analyzed the transition state for folding of the three-helix bundle protein, by using experimental Φ values on some 70 suitable mutants. Surprisingly...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406447/ https://ncbi.nlm.nih.gov/pubmed/15069202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0401396101 |
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