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Stable down-regulation of human polynucleotide kinase enhances spontaneous mutation frequency and sensitizes cells to genotoxic agents
Human polynucleotide kinase (hPNK) is a 57.1-kDa monomeric protein with conserved motifs associated with phosphatase and kinase activities. hPNK catalyzes phosphorylation of 5′-DNA termini and dephosphorylation of 3′-DNA termini. Previous studies, employing cell-free systems, have suggested that hPN...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2004
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC406440/ https://ncbi.nlm.nih.gov/pubmed/15100409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400099101 |
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