Genetic or Pharmacologic Activation of Nrf2 Signaling Fails to Protect Against Aflatoxin Genotoxicity in Hypersensitive GSTA3 Knockout Mice

Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, which controls a broad-based cytoprotective response, was activated either genetic...

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Main Authors: Kensler, Kevin H., Slocum, Stephen L., Chartoumpekis, Dionysios V., Dolan, Patrick M., Johnson, Natalie M., Ilic, Zoran, Crawford, Dana R., Sell, Stewart, Groopman, John D., Kensler, Thomas W., Egner, Patricia A.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Biotransformation and Toxicokinetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064015/
https://ncbi.nlm.nih.gov/pubmed/24675090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu056
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