Genetic or Pharmacologic Activation of Nrf2 Signaling Fails to Protect Against Aflatoxin Genotoxicity in Hypersensitive GSTA3 Knockout Mice

Mice are resistant to aflatoxin hepatotoxicity, primarily due to high expression of glutathione S-transferases (GSTs), and in particular the GSTA3 subunit. Nuclear factor erythroid 2 related factor 2 (Nrf2) signaling, which controls a broad-based cytoprotective response, was activated either genetic...

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Hlavní autoři: Kensler, Kevin H., Slocum, Stephen L., Chartoumpekis, Dionysios V., Dolan, Patrick M., Johnson, Natalie M., Ilic, Zoran, Crawford, Dana R., Sell, Stewart, Groopman, John D., Kensler, Thomas W., Egner, Patricia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Biotransformation and Toxicokinetics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4064015/
https://ncbi.nlm.nih.gov/pubmed/24675090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu056
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