Connective tissue growth factor (CCN2) and microRNA-21 are components of a positive feedback loop in pancreatic stellate cells (PSC) during chronic pancreatitis and are exported in PSC-derived exosomes

Pancreatitis is an inflammatory condition of the pancreas which, in its chronic form, involves tissue destruction, exocrine and endocrine insufficiency, increased risk of pancreatic cancer, and an extensive fibrotic pathology which is due to unrelenting collagen deposition by pancreatic stellate cel...

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Bibliographic Details
Main Authors: Charrier, Alyssa, Chen, Ruju, Chen, Li, Kemper, Sherri, Hattori, Takako, Takigawa, Masaharu, Brigstock, David R.
Format: Artigo
Language:Inglês
Published: Springer Netherlands 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063995/
https://ncbi.nlm.nih.gov/pubmed/24464300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12079-014-0220-3
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