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Di-Tyrosine Cross-Link Decreases the Collisional Cross-Section of Aβ Peptide Dimers and Trimers in the Gas Phase: An Ion Mobility Study

Oligomeric forms of Aβ peptide are most likely the main synaptotoxic and neurotoxic agent in Alzheimer’s disease. Toxicity of various Aβ oligomeric forms has been confirmed in vivo and also in vitro. However, in vitro preparations were found to be orders of magnitude less toxic than oligomers obtain...

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Detalhes bibliográficos
Main Authors: Sitkiewicz, Ewa, Olędzki, Jacek, Poznański, Jarosław, Dadlez, Michał
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063900/
https://ncbi.nlm.nih.gov/pubmed/24945725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100200
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