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Cell-based assay for the detection of chemically induced cellular stress by immortalized untransformed transgenic hepatocytes

BACKGROUND: Primary hepatocytes, one of the most widely used cell types for toxicological studies, have a very limited life span and must be freshly derived from mice or even humans. Attempts to use stable cell lines maintaining the enzymatic pattern of liver cells have been so far unsatisfactory. S...

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Detalhes bibliográficos
Main Authors: Sacco, Maria Grazia, Amicone, Laura, Catò, Enrica Mira, Filippini, Daniela, Vezzoni, Paolo, Tripodi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC406386/
https://ncbi.nlm.nih.gov/pubmed/15033002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-4-5
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