Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.

Hepatocyte growth factor induces proliferation, motility and differentiation of epithelial cells through the tyrosine kinase receptor encoded by the MET protooncogene. The cytoplasmic portion of Met (referred to as cyto-Met) is activated but only weakly transforming. In order to determine the effect...

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Bibliographic Details
Main Authors:	Amicone, L, Spagnoli, F M, Späth, G, Giordano, S, Tommasini, C, Bernardini, S, De Luca, V, Della Rocca, C, Weiss, M C, Comoglio, P M, Tripodi, M
Format:	Artigo
Language:	Inglês
Published:	1997
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1169653/ https://ncbi.nlm.nih.gov/pubmed/9034332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/16.3.495
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Transgenic expression in the liver of truncated Met blocks apoptosis and permits immortalization of hepatocytes.

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