Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system

UCHL1 (ubiquitin carboxyterminal hydrolase 1) is a deubiquitinating enzyme that is particularly abundant in neurons. From studies of a spontaneous mutation arising in a mouse line it is clear that loss of function of UCHL1 generates profound degenerative changes in the central nervous system, and it...

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Detalhes bibliográficos
Main Authors: Coulombe, Josée, Gamage, Prasanna, Gray, Madison T., Zhang, Mei, Tang, Matthew Y., Woulfe, John, Saffrey, M. Jill, Gray, Douglas A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4063237/
https://ncbi.nlm.nih.gov/pubmed/24994982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2014.00129
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