RISC is a 5′ phosphomonoester-producing RNA endonuclease

Gene silencing in the process of RNA interference is mediated by a ribonucleoprotein complex referred to as RNA-induced silencing complex (RISC). Here we describe the molecular mechanism of target RNA cleavage using affinity-purified minimal RISC from human cells. Cleavage proceeds via hydrolysis an...

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Bibliografische Detailangaben

Veröffentlicht in:	Genes Dev
Hauptverfasser:	Martinez, Javier, Tuschl, Thomas
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Cold Spring Harbor Laboratory Press 2004
Schlagworte:	Research Communications
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC406288/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15105377/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1187904
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