Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation

Transient receptor potential A1 (TRPA1) is implicated in somatosensory processing and pathological pain sensation. Although not strictly voltage-gated, ionic currents of TRPA1 typically rectify outwardly, indicating channel activation at depolarized membrane potentials. However, some reports also sh...

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Detalhes bibliográficos
Main Authors: Wan, Xia, Lu, Yungang, Chen, Xueqin, Xiong, Jian, Zhou, Yuanda, Li, Ping, Xia, Bingqing, Li, Min, Zhu, Michael X., Gao, Zhaobing
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2013
Assuntos:
Ion Channels, Receptors and Transporters
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062818/
https://ncbi.nlm.nih.gov/pubmed/24092046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00424-013-1345-6
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