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CD4(+) T Cell Subset Differentiation and Avidity Setpoint Are Dictated by the Interplay of Cytokine and Antigen Mediated Signals

CD4(+) T cell differentiation has been shown to be regulated by the cytokine milieu present during activation as well as peptide MHC levels. However, the extent to which these two important regulatory signals work in concert to shape CD4(+) T cell function has not been investigated. Using a murine O...

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Detalhes bibliográficos
Main Authors: Shiner, Erin K., Holbrook, Beth C., Alexander-Miller, Martha A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062528/
https://ncbi.nlm.nih.gov/pubmed/24940899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0100175
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