Llwytho...

Membrane-localized Estrogen Receptor Alpha is Required for Normal Organ Development and Function

Steroid receptors are found in discrete cellular locations but it is unknown whether extra-nuclear pools are necessary for normal organ development. To assess this we developed a point-mutant estrogen receptor alpha (ERα) knock-in mouse (C451A) that precludes palmitoylation and membrane trafficking...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Pedram, Ali, Razandi, Mahnaz, Lewis, Michael, Hammes, Stephen, Levin, Ellis R
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062189/
https://ncbi.nlm.nih.gov/pubmed/24871949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2014.04.016
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