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Structural insight into activity enhancement and inhibition of H64A carbonic anhydrase II by imidazoles
Human carbonic anhydrases (CAs) are zinc metalloenzymes that catalyze the hydration and dehydration of CO(2) and HCO(3) (−), respectively. The reaction follows a ping-pong mechanism, in which the rate-limiting step is the transfer of a proton from the zinc-bound solvent (OH(−)/H(2)O) in/out of the a...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
International Union of Crystallography
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4062085/ https://ncbi.nlm.nih.gov/pubmed/25075329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2052252514004096 |
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