A genome scale overexpression screen to reveal drug activity in human cells

Target identification is a critical step in the lengthy and expensive process of drug development. Here, we describe a genome-wide screening platform that uses systematic overexpression of pooled human ORFs to understand drug mode-of-action and resistance mechanisms. We first calibrated our screen w...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Arnoldo, Anthony, Kittanakom, Saranya, Heisler, Lawrence E, Mak, Anthony B, Shukalyuk, Andrey I, Torti, Dax, Moffat, Jason, Giaever, Guri, Nislow, Corey
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2014
Materias:
Method
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4062067/
https://ncbi.nlm.nih.gov/pubmed/24944581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm549
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares