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A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.

To examine the in vivo role(s) of type I interferons (IFNs) and to determine the role of a component of the type I IFN receptor (IFNAR1) in mediating responses to these IFNs, we generated mice with a null mutation (-/-) in the IFNAR1 gene. Despite compelling evidence for modulation of cell prolifera...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Hwang, S Y, Hertzog, P J, Holland, K A, Sumarsono, S H, Tymms, M J, Hamilton, J A, Whitty, G, Bertoncello, I, Kola, I
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40616/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479980/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11284
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