The Human Orphan Nuclear Receptor Tailless (TLX, NR2E1) Is Druggable

Nuclear receptors (NRs) are an important group of ligand-dependent transcriptional factors. Presently, no natural or synthetic ligand has been identified for a large group of orphan NRs. Small molecules to target these orphan NRs will provide unique resources for uncovering regulatory systems that i...

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Bibliographic Details
Main Authors: Benod, Cindy, Villagomez, Rosa, Filgueira, Carly S., Hwang, Peter K., Leonard, Paul G., Poncet-Montange, Guillaume, Rajagopalan, Senapathy, Fletterick, Robert J., Gustafsson, Jan-Åke, Webb, Paul
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060991/
https://ncbi.nlm.nih.gov/pubmed/24936658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0099440
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