Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging

Macromolecular Gd(III) based contrast agents are effective for contrast enhanced blood pool and cancer MRI in preclinical studies. However, their clinical applications are impeded by potential safety concerns associated with slow excretion and prolonged retention of these agents in the body. To mini...

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Bibliographic Details
Main Authors: Ye, Zhen, Wu, Xueming, Tan, Mingqian, Jesberger, Jack, Griswold, Mark, Lu, Zheng-Rong
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060968/
https://ncbi.nlm.nih.gov/pubmed/23606425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.1520
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