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Synthesis and evaluation of a polydisulfide with Gd-DOTA monoamide side chains as a biodegradable macromolecular contrast agent for MR blood pool imaging

Macromolecular Gd(III) based contrast agents are effective for contrast enhanced blood pool and cancer MRI in preclinical studies. However, their clinical applications are impeded by potential safety concerns associated with slow excretion and prolonged retention of these agents in the body. To mini...

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Detalhes bibliográficos
Main Authors: Ye, Zhen, Wu, Xueming, Tan, Mingqian, Jesberger, Jack, Griswold, Mark, Lu, Zheng-Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060968/
https://ncbi.nlm.nih.gov/pubmed/23606425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmmi.1520
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