Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging

[Image: see text] Bexarotene (Targretin) is a retinoid X receptor (RXR) agonist that has applications for treatment of T cell lymphoma and proposed mechanisms of action in Alzheimer’s disease that have been the subject of recent controversy. Carbon-11 labeled bexarotene ([(11)C-carbonyl]4-[1-(3,5,5,...

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Bibliographic Details
Main Authors: Rotstein, Benjamin H., Hooker, Jacob M., Woo, Jiyeon, Collier, Thomas Lee, Brady, Thomas J., Liang, Steven H., Vasdev, Neil
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060930/
https://ncbi.nlm.nih.gov/pubmed/24944741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500065q
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