Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

[Image: see text] We report the discovery of novel imidazo[4,5-b]pyridines as potent and selective inhibitors of PDE10A. The investigation began with our recently disclosed ketobenzimidazole 1, which exhibited single digit nanomolar PDE10A activity but poor oral bioavailability. To improve oral bioa...

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Główni autorzy: Hu, Essa, Andrews, Kristin, Chmait, Samer, Zhao, Xiaoning, Davis, Carl, Miller, Silke, Hill Della Puppa, Geraldine, Dovlatyan, Mary, Chen, Hang, Lester-Zeiner, Dianna, Able, Jessica, Biorn, Christopher, Ma, Ji, Shi, Jianxia, Treanor, James, Allen, Jennifer R.
Format: Artigo
Język:Inglês
Wydane: American Chemical Society 2014
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060924/
https://ncbi.nlm.nih.gov/pubmed/24944747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5000993
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