Discovery of Novel Imidazo[4,5-b]pyridines as Potent and Selective Inhibitors of Phosphodiesterase 10A (PDE10A)

[Image: see text] We report the discovery of novel imidazo[4,5-b]pyridines as potent and selective inhibitors of PDE10A. The investigation began with our recently disclosed ketobenzimidazole 1, which exhibited single digit nanomolar PDE10A activity but poor oral bioavailability. To improve oral bioa...

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Detalhes bibliográficos
Main Authors: Hu, Essa, Andrews, Kristin, Chmait, Samer, Zhao, Xiaoning, Davis, Carl, Miller, Silke, Hill Della Puppa, Geraldine, Dovlatyan, Mary, Chen, Hang, Lester-Zeiner, Dianna, Able, Jessica, Biorn, Christopher, Ma, Ji, Shi, Jianxia, Treanor, James, Allen, Jennifer R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060924/
https://ncbi.nlm.nih.gov/pubmed/24944747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5000993
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