PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

The molecular mechanisms underlying the development of pancreatic neuroendocrine tumors (PanNETs) have not been well defined. We report here that the genomic region of the PHLDA3 gene undergoes loss of heterozygosity (LOH) at a remarkably high frequency in human PanNETs, and this genetic change is c...

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Detalhes bibliográficos
Main Authors: Ohki, Rieko, Saito, Kozue, Chen, Yu, Kawase, Tatsuya, Hiraoka, Nobuyoshi, Saigawa, Raira, Minegishi, Maiko, Aita, Yukie, Yanai, Goichi, Shimizu, Hiroko, Yachida, Shinichi, Sakata, Naoaki, Doi, Ryuichiro, Kosuge, Tomoo, Shimada, Kazuaki, Tycko, Benjamin, Tsukada, Toshihiko, Kanai, Yae, Sumi, Shoichiro, Namiki, Hideo, Taya, Yoichi, Shibata, Tatsuhiro, Nakagama, Hitoshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060701/
https://ncbi.nlm.nih.gov/pubmed/24912192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1319962111
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