Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation.
The progress toward single-dose vaccines has been limited by the poor solid-state stability of vaccine antigens within controlled-release polymers, such as poly(lactide-co-glycolide). For example, herein we report that lyophilized tetanus toxoid aggregates during incubation at 37 degrees C and eleva...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1995
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40606/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479971/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11234 |
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