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Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation.

The progress toward single-dose vaccines has been limited by the poor solid-state stability of vaccine antigens within controlled-release polymers, such as poly(lactide-co-glycolide). For example, herein we report that lyophilized tetanus toxoid aggregates during incubation at 37 degrees C and eleva...

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Hlavní autoři: Schwendeman, S P, Costantino, H R, Gupta, R K, Siber, G R, Klibanov, A M, Langer, R
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC40606/
https://ncbi.nlm.nih.gov/pubmed/7479971
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