Stabilization of tetanus and diphtheria toxoids against moisture-induced aggregation.

The progress toward single-dose vaccines has been limited by the poor solid-state stability of vaccine antigens within controlled-release polymers, such as poly(lactide-co-glycolide). For example, herein we report that lyophilized tetanus toxoid aggregates during incubation at 37 degrees C and eleva...

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Main Authors: Schwendeman, S P, Costantino, H R, Gupta, R K, Siber, G R, Klibanov, A M, Langer, R
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC40606/
https://ncbi.nlm.nih.gov/pubmed/7479971
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