Metabolic memory of ß-cells controls insulin secretion and is mediated by CaMKII

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) functions both in regulation of insulin secretion and neurotransmitter release through common downstream mediators. Therefore, we hypothesized that pancreatic ß-cells acquire and store the information contained in calcium pulses as a form of “me...

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Autors principals: Santos, Gustavo Jorge dos, Ferreira, Sandra Mara, Ortis, Fernanda, Rezende, Luiz Fernando, Li, Chengyang, Naji, Ali, Carneiro, Everardo Magalhães, Kaestner, Klaus H., Boschero, Antonio Carlos
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2014
Matèries:
Brief Communication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4060215/
https://ncbi.nlm.nih.gov/pubmed/24944908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2014.03.011
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