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Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

The immunosuppressive drugs cyclosporin A and FK506 interfere with the inducible transcription of cytokine genes in T cells and in other immune cells, in part by preventing the activation of NF-AT (nuclear factor of activated T cells). We show that transcription factor NFAT1 in T cells is rapidly de...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Shaw, K T, Ho, A M, Raghavan, A, Kim, J, Jain, J, Park, J, Sharma, S, Rao, A, Hogan, P G
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40600/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7479966/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.24.11205
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