Immunosuppressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells.

The immunosuppressive drugs cyclosporin A and FK506 interfere with the inducible transcription of cytokine genes in T cells and in other immune cells, in part by preventing the activation of NF-AT (nuclear factor of activated T cells). We show that transcription factor NFAT1 in T cells is rapidly de...

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Hlavní autoři: Shaw, K T, Ho, A M, Raghavan, A, Kim, J, Jain, J, Park, J, Sharma, S, Rao, A, Hogan, P G
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC40600/
https://ncbi.nlm.nih.gov/pubmed/7479966
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