Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity

The emerging role of the transient receptor potential cation channel isotype 6 (TRPC6) as a central contributor to various pathological processes affecting podocytes has generated interest in the development of therapeutics to modulate its function. Recent insights into the regulation of TRPC6 have...

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Autori principali: Hall, Gentzon, Rowell, Janelle, Farinelli, Federica, Gbadegesin, Rasheed A., Lavin, Peter, Wu, Guanghong, Homstad, Alison, Malone, Andrew, Lindsey, Thomas, Jiang, Ruiji, Spurney, Robert, Tomaselli, Gordon F., Kass, David A., Winn, Michelle P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059973/
https://ncbi.nlm.nih.gov/pubmed/24740790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00212.2013
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