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Relevance of liver failure for anti-infective agents: from pharmacokinetic alterations to dosage adjustments
The liver is a complex organ with great ability to influence drug pharmacokinetics (PK). Due to its wide array of function, its impairment has the potential to affect bioavailability, enterohepatic circulation, drug distribution, metabolism, clearance, and biliary elimination. These alterations diff...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
SAGE Publications
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059611/ https://ncbi.nlm.nih.gov/pubmed/24949199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2049936113519089 |
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