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FRET Study of the Structural and Kinetic Effects of PKC Phosphomimetic Cardiac Troponin T Mutants on Thin Filament Regulation
FRET was used to investigate the structural and kinetic effects that PKC phosphorylations exert on Ca2+ and myosin subfragment-1 dependent conformational transitions of the cardiac thin filament. PKC phosphorylations of cTnT were mimicked by glutamate substitution. Ca2+ and S1-induced distance chang...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4059398/ https://ncbi.nlm.nih.gov/pubmed/24708997 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.03.013 |
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