The Role of Select Subtype Polymorphisms on HIV-1 Protease Conformational Sampling and Dynamics

HIV-1 protease is an essential enzyme for viral particle maturation and is a target in the fight against HIV-1 infection worldwide. Several natural polymorphisms are also associated with drug resistance. Here, we utilized both pulsed electron double resonance, also called double electron-electron re...

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Detalhes bibliográficos
Main Authors: Huang, Xi, Britto, Manuel D., Kear-Scott, Jamie L., Boone, Christopher D., Rocca, James R., Simmerling, Carlos, Mckenna, Robert, Bieri, Michael, Gooley, Paul R., Dunn, Ben M., Fanucci, Gail E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059161/
https://ncbi.nlm.nih.gov/pubmed/24742668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.571836
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