Differential Interaction of Tomosyn with Syntaxin and SNAP25 Depends on Domains in the WD40 β-Propeller Core and Determines Its Inhibitory Activity

Neuronal exocytosis depends on efficient formation of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes and is regulated by tomosyn, a SNARE-binding protein. To gain new information about tomosyn's activity, we characterized its mobility and organization on...

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Autores principales: Bielopolski, Noa, Lam, Alice D., Bar-On, Dana, Sauer, Markus, Stuenkel, Edward L., Ashery, Uri
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059150/
https://ncbi.nlm.nih.gov/pubmed/24782308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.515296
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