Targeting the Transient Receptor Potential Vanilloid Type 1 (TRPV1) Assembly Domain Attenuates Inflammation-induced Hypersensitivity

The transient receptor potential channel vanilloid type 1 (TRPV1) is a non-selective cation channel expressed in sensory neurons of the dorsal root and trigeminal ganglia. TRPV1 is a polymodal channel activated by noxious heat, capsaicin, and protons. As a sensor for noxious stimuli, TRPV1 channel h...

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Autores principales: Flynn, Robyn, Chapman, Kevin, Iftinca, Mircea, Aboushousha, Reem, Varela, Diego, Altier, Christophe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059113/
https://ncbi.nlm.nih.gov/pubmed/24808184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558668
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