Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading to potential adverse events and safety concerns. We have developed a synthetic...

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Detalhes bibliográficos
Main Authors: Ilyinskii, Petr O., Roy, Christopher J., O’Neil, Conlin P., Browning, Erica A., Pittet, Lynnelle A., Altreuter, David H., Alexis, Frank, Tonti, Elena, Shi, Jinjun, Basto, Pamela A., Iannacone, Matteo, Radovic-Moreno, Aleksandar F., Langer, Robert S., Farokhzad, Omid C., von Andrian, Ulrich H., Johnston, Lloyd P.M., Kishimoto, Takashi Kei
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4059049/
https://ncbi.nlm.nih.gov/pubmed/24593999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2014.02.027
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