Variants in the ATM-CHEK2-BRCA1 Axis Determine Genetic Predisposition and Clinical Presentation of Papillary Thyroid Carcinoma

The risk of developing papillary thyroid carcinoma (PTC), the most frequent form of thyroid malignancy, is elevated up to 8.6-fold in first-degree relatives of PTC patients. The familial risk could be explained by high-penetrance mutations in yet unidentified genes, or polygenic action of low-penetr...

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Detalhes bibliográficos
Main Authors: Wójcicka, Anna, Czetwertyńska, Małgorzata, Œwierniak, Michał, Długosińska, Joanna, Maciąg, Monika, Czajka, Agnieszka, Dymecka, Kinga, Kubiak, Anna, Kot, Adam, Płoski, Rafał, de la Chapelle, Albert, Jażdżewski, Krystian
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058861/
https://ncbi.nlm.nih.gov/pubmed/24599715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.22162
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