A New Domain in the Toll/IL-1R Domain-Containing Adaptor Inducing Interferon-ß Factor Protein Amino Terminus Is Important for Tumor Necrosis Factor-a Receptor-Associated Factor 3 Association, Protein Stabilization and Interferon Signaling

Toll/IL-1R domain-containing adaptor inducing interferon-ß (IFN-ß) factor (TRIF) is a key adaptor for Toll-like receptor (TLR) 3 and TLR4 signaling. Using a novel cDNA isolate encoding a TRIF protein with a 21-residue deletion (Δ160-181) from its amino-terminal half, we investigated the impact of th...

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Detalhes bibliográficos
Main Authors: Nguyen, Vinh-Phuc, Chen, Jing, Petrus, Michael N., Goldman, Carolyn K., Kruhlak, Michael J., Bamford, Richard N., Waldmann, Thomas A.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058787/
https://ncbi.nlm.nih.gov/pubmed/24577058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000356408
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