The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERα(+) breast cancer cells

In this study, we demonstrate that constitutive activation of Raf-1 oncogenic signaling induces stabilization and accumulation of Aurora-A mitotic kinase that ultimately drives the transition from an epithelial to a highly invasive mesenchymal phenotype in estrogen receptor α-positive (ERα(+)) breas...

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Main Authors: D'Assoro, AB, liu, T, Quatraro, C, Amato, A, Opyrchal, M, Leontovich, A, Ikeda, Y, Ohmine, S, Lingle, W, Suman, V, Ecsedy, J, Iankov, I, Di Leonardo, A, Ayers-Inglers, J, Degnim, A, Billadeau, D, McCubrey, J, Ingle, J, Salisbury, JL, Galanis, E
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058768/
https://ncbi.nlm.nih.gov/pubmed/23334326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2012.628
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