Trastuzumab emtansine is active on HER-2 overexpressing NSCLC cell lines and overcomes gefitinib resistance

BACKGROUND: HER-2 represents a relatively new therapeutic target for non small cell lung cancer (NSCLC) patients. The incidence for reported HER-2 overexpression/amplification/mutations ranges from 2 to 20% in NSCLC. Moreover, HER-2 amplification is a potential mechanism of resistance to tyrosine ki...

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Detalhes bibliográficos
Main Authors: Cretella, Daniele, Saccani, Francesca, Quaini, Federico, Frati, Caterina, Lagrasta, Costanza, Bonelli, Mara, Caffarra, Cristina, Cavazzoni, Andrea, Fumarola, Claudia, Galetti, Maricla, La Monica, Silvia, Ampollini, Luca, Tiseo, Marcello, Ardizzoni, Andrea, Petronini, Pier Giorgio, Alfieri, Roberta R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058446/
https://ncbi.nlm.nih.gov/pubmed/24898067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-143
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