SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines

OBJECTIVES: Primary and acquired resistance to EGFR TKIs in EGFR mutant lung cancer occurs primarily through secondary mutations in EGFR or Met amplification. Drug resistance can also be mediated by expression of pluripotency transcription factors, such as OCT4, SOX2 and NANOG that decrease terminal...

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Hoofdauteurs: Dogan, Irem, Kawabata, Shigeru, Bergbower, Emily, Gills, Joell J., Ekmekci, Abdullah, Wilson, Willie, Rudin, Charles M., Dennis, Phillip A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058091/
https://ncbi.nlm.nih.gov/pubmed/24746758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2014.03.021
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