SOX2 expression is an early event in a murine model of EGFR mutant lung cancer and promotes proliferation of a subset of EGFR mutant lung adenocarcinoma cell lines

OBJECTIVES: Primary and acquired resistance to EGFR TKIs in EGFR mutant lung cancer occurs primarily through secondary mutations in EGFR or Met amplification. Drug resistance can also be mediated by expression of pluripotency transcription factors, such as OCT4, SOX2 and NANOG that decrease terminal...

Full description

Saved in:
Bibliographic Details
Main Authors: Dogan, Irem, Kawabata, Shigeru, Bergbower, Emily, Gills, Joell J., Ekmekci, Abdullah, Wilson, Willie, Rudin, Charles M., Dennis, Phillip A.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058091/
https://ncbi.nlm.nih.gov/pubmed/24746758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.lungcan.2014.03.021
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items