Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway

The far-upstream element-binding protein-interacting repressor (FIR) is a c-myc transcriptional suppressor. FIR is alternatively spliced to lack the transcriptional repression domain within exon 2 (FIRΔexon2) in colorectal cancers. FIR and FIRΔexon2 form homo- or heterodimers that complex with SAP15...

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Autors principals: Rahmutulla, Bahityar, Matsushita, Kazuyuki, Satoh, Mamoru, Seimiya, Masanori, Tsuchida, Sachio, Kubo, Shuji, Shimada, Hideaki, Ohtsuka, Masayuki, Miyazaki, Masaru, Nomura, Fumio
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2013
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058014/
https://ncbi.nlm.nih.gov/pubmed/24811221
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