The KLK5 protease suppresses breast cancer by repressing the mevalonate pathway

Kallikrein-related peptidase 5 (KLK5) displays aberrant expression in cancer. However, any functional association is missing. Here, we show that reconstitution of KLK5 expression in non-expressing MDA-MB-231 breast cancer cells suppresses malignancy in vitro and in vivo dose-dependently. Reactivatio...

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Bibliografiska uppgifter
Huvudupphovsmän: Pampalakis, Georgios, Obasuyi, Osahon, Papadodima, Olga, Chatziioannou, Aristotelis, Zoumpourlis, Vassileios, Sotiropoulou, Georgia
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2013
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4058013/
https://ncbi.nlm.nih.gov/pubmed/24158494
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