Antagonism of WT1 activity by protein self-association.

Germline loss-of-function mutations at the Wilms tumor (WT) suppressor locus WT1 are associated with a predisposition to WTs and mild genital system anomalies. In contrast, germ-line missense mutations within the WT1 gene encoding the DNA-binding domain often yield a more severe phenotype consisting...

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Autores principales: Moffett, P, Bruening, W, Nakagama, H, Bardeesy, N, Housman, D, Housman, D E, Pelletier, J
Formato: Artigo
Lenguaje:Inglês
Publicado: 1995
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC40580/
https://ncbi.nlm.nih.gov/pubmed/7479946
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