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Changes in dermal fibroblasts from Abcc6−/− mice are present before and after the onset of ectopic tissue mineralization
Pseudoxanthoma elasticum (PXE), a rare genetic disease caused by mutations in the ABCC6 gene, is characterized by progressive calcification of elastic fibers in the skin, eyes and the cardiovascular system. The pathomechanisms of the mineralization is still obscure. Several hypotheses have been prop...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4057957/ https://ncbi.nlm.nih.gov/pubmed/24670382 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2014.88 |
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