Characterization of the isomeric configuration and impurities of (Z)-endoxifen by 2D NMR, high resolution LC–MS, and quantitative HPLC analysis

(Z)-Endoxifen (4-hydroxy-N-desmethyltamoxifen), an active metabolite generated via actions of CYP3A4/5 and CYP2D6, is a more potent selective estrogen receptor modulator (SERM) than tamoxifen. In the MCF-7 human mammary tumor xenograft model with female athymic mice, (Z)-endoxifen, at an oral dose o...

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Detalhes bibliográficos
Main Authors: Elkins, Phyllis, Coleman, Donna, Burgess, Jason, Gardner, Michael, Hines, John, Scott, Brendan, Kroenke, Michelle, Larson, Jami, Lightner, Melissa, Turner, Gregory, White, Jonathan, Liu, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057282/
https://ncbi.nlm.nih.gov/pubmed/24055701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2013.07.010
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