Nucleosomal Histone Proteins of L. donovani: A Combination of Recombinant H2A, H2B, H3 and H4 Proteins Were Highly Immunogenic and Offered Optimum Prophylactic Efficacy against Leishmania Challenge in Hamsters

The present study includes cloning and expression of recombinant Leishmania donovani histone proteins (rLdH2B, rLdH3, rLdH2A and rLdH4), assessment of their immunogenicity in Leishmania infected cured patients/endemic contacts as well as in cured hamsters and finally evaluation of their prophylactic...

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Bibliographic Details
Main Authors: Baharia, Rajendra K., Tandon, Rati, Sahasrabuddhe, Amogh A., Sundar, Shyam, Dube, Anuradha
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057088/
https://ncbi.nlm.nih.gov/pubmed/24926878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0097911
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